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Figure 4. KCNE2 differentially affects Kv4.3L and Kv4.3S function with/without KChIP2b. (A) Mean ± SEM peak current/voltage relationship for current traces recorded from Xenopus oocytes 36–48 h after injection of cRNA encoding Kv4.3L or Kv4.3S (1 ng) with KCNE2 (5 ng), with or without KChIP2 (5 ng; n = 14–18). Inset: Voltage clamp protocol. ***P < 0.001 compared to Kv4.3L-KChIP2-KCNE2 at +40 mV. (B) Box plot showing individual and mean ± SEM values for τ of inactivation (single exponential fit) for currents recorded as in (A); n = 14–18. NS, P > 0.05; ***P < 5 × 10−14. (C) Mean ± SEM fraction of available channels/voltage relationship for Kv4.3L-KCNE2 vs. Kv4.3S-KCNE2 (upper) and Kv4.3L-KCNE2-KChIP2 vs. Kv4.3S-KCNE2-KChIP2 (lower) currents; voltage protocol upper right inset; n = 6. (D) Mean ± SEM fractional recovery from inactivation/recovery time for Kv4.3L-KCNE2 vs. Kv4.3S-KCNE2 (upper) and Kv4.3L-KCNE2-KChIP2 vs. Kv4.3S-KCNE2-KChIP2 (lower) currents; voltage protocol upper inset; n = 5–7. Image published in: Abbott GW (2017) Copyright © 2017 Abbott. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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