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Fig. 6. Loss of N4bp3 leads to an impaired neural crest cell migration. WMISH experiments show a mild effect on neural crest marker genes snai2, foxd3 and twist1 at stage 16 upon N4bp3 deficiency (arrows). In contrast, Control MO injections have no influence in neural crest marker genes at this stage. Statistical evaluation of the data is given. B Neural crest cell migration at stage 24 is severely impaired after N4bp3 depletion whereas Control MO injections show no effect. Statistical evaluation of the data is given. Abbreviations: N, number of evaluated embryos in total; n, number of independent experiments. Error bars indicate standard error of the means (s. e. m.); * p≤0.05. P-values were calculated by a nonparametric, one-tailed Mann-Whitney rank sum test. Image published in: Kiem LM et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Gene Synonyms Species Stage(s) Tissue snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 16 neural crest cranial neural crest trunk neural crest anterior branchial crest posterior branchial crest vagal neural crest sacral neural crest premigratory neural crest cell snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 24 neural crest cranial neural crest vagal neural crest sacral neural crest migratory neural crest cell foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 16 neural crest cranial neural crest trunk neural crest vagal neural crest sacral neural crest migratory neural crest cell premigratory neural crest cell foxd3.L fkh6, foxd3-a, foxd3-b, XFD-6, xfoxd3 X. laevis Throughout NF stage 23 neural crest cranial neural crest trunk neural crest vagal neural crest sacral neural crest migratory neural crest cell twist1.L twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 16 neural crest cranial neural crest premigratory neural crest cell anterior branchial crest posterior branchial crest twist1.L twist, twist1-a, twist1-b, X-twi, Xtwi, Xtwist X. laevis Throughout NF stage 23 neural crest cranial neural crest migratory neural crest cell egr2.L EGR-2, Krox-20, krox20, XKr20, XKrox-20 X. laevis Throughout NF stage 23 rhombomere rhombomere R3 rhombomere R5 neural crest premigratory neural crest cell migratory neural crest cell cranial neural crest Image source: Published Larger Image Printer Friendly View

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