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Fig. 7. TUNEL and pH3 staining in N4bp3-deficient embryos at stage 23. A TUNEL staining. N4bp3 MO injection leads to an increase of TUNEL positive cells compared to the un-injected side whereas the Control MO injection has no effect on cell apoptosis. TUNEL positive cells were counted in the areas defined by the black rectangles. Statistical quantifications of the data are given. B N4bp3 depletion leads to a significant reduction of proliferating cells compared to the un-injected side whereas the Control MO injection has no influence on cell proliferation. pH3 positive cells were counted in the areas defined by the black rectangles. Statistical evaluation of the data are shown. Abbreviations: n, number of independent experiments; n.s., not significant. Error bars indicate standard error of the means (s. e. m.); ** p≤0.01; **** p≤0.0001. P-values were calculated by a nonparametric, one-tailed Mann-Whitney rank sum test. Image published in: Kiem LM et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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