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Figure 8. Tranilast inhibits urate transport mediated by the human urate transporter NPT1. The uptake of [14C]‐urate by NPT1‐expressing oocytes was performed in ND96 medium (pH 7.4) at ~25°C for 1 h. The [14C]‐urate uptake by NPT1‐expressing oocytes was found little trans‐stimulated when NPT1‐expressing oocytes were preinjected with 50 nL of 100 mmol/L nicotinate (Nico) 2 h before [14C]‐urate uptake experiment. The [14C]‐urate uptake by NPT1 was found substantially inhibited in the presence of extracellular organic anions or uricosuric drugs. Organic anions or uricosuric drugs were added to the extracellular medium (pH 7.4) at the indicated concentrations. *P < 0.001 compared with uptake in the presence of DMSO or in the absence of inhibitor. Tran, Benz, Prob, DMSO, PZA, Sal. Data are mean ± S.E. with n = 12–15. PZA, pyrazine carboxylate; Tran, Tranilast; Benz, Benzbromarone; Prob, probenecid; DMSO, dimethylsulfoxide. Image published in: Mandal AK et al. (2017) © 2017 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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