Xenbase Image ID: 156525

Figure 2. Aggregation Suppression by the DNAJB Subfamily Was Found for Various Misfolded Model Proteins (A) Confocal micrographs of nuclear-targeted EGFP-HDQ23 and EGFP-HDQ74. (B) Filter trap analysis (bottom) on nuclear-targeted EGFP-HDQ74 aggregation. Top panel shows western blot of the chaperones. (C) Confocal micrographs of cells expressing EYFP-SCA3-22Q or EYFP-SCA3-82Q. (D and E) Western blot (D) and filter trap (E) analysis of EYFP-SCA3-22Q or EYFP-SCA3-82Q, details as in Figure 1. (F and G) Western blot (F) and filter trap (G) analysis of cells transfected with constructs encoding untagged androgen receptor containing 24 or 74 glutamines (detected with an anti-androgen receptor antibody). Details as in Figure 1. Image published in: Hageman J et al. (2010) Copyright © 2010. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

Return to previous page