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Fig 1. Anteroposterior axis is rescued by ectopic Hox expression in noggin-dorsalised embryos.
(A) Morphological phenotypes of embryos in different Hox rescue treatments. Anterior is to the left and dorsal is up. (B) Percentage of embryos showing different phenotypes in different treatment groups. From left to right: wild-type (n = 40); Noggin only (n = 32); Noggin and HoxD-1 co-injection (n = 133); HoxB-4 GR and Noggin co-injection, without Dex treatment (n = 46); HoxB4 and Noggin co-injection, with Dex treatment at st.8 (n = 90); HoxB-9 and Noggin co-injection: n = 140. (C-E) Q-PCR for HoxD-1, HoxB-4, HoxC-6 and HoxB-9 in different rescue groups: rescue by HoxD1 (C), rescue by HoxB4 (D), and rescue by HoxB-9. Data are represented as mean ± SEM. (F) Schematic showing different portions of A-P axis and different Hox genes rescued by HoxD1, B4 and B9 respectively.
https://doi.org/10.1371/journal.pone.0175287.g001 Image published in: Zhu K et al. (2017) © 2017 Zhu et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |