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Fig. 4.
Eye marker gene expression upon Fzd3 and Alcam deficiency. After depletion of Fzd3 (A) or Alcam (B), rax and pax6 expression in the eye field was slightly but significantly reduced at stage 13 compared to Control MO injected sides as shown by WMISH. In contrast, otx2 and sox3 were unaffected upon Alcam or Fzd3 MO injection. At stage 23, expression of rax, pax6, and otx2 in the eye region was reduced after loss of either Fzd3 (C) or Alcam (D) in comparison to Control MO injected embryos. Quantitative representations are given. Abbreviations: inj., injected; n, number of independent experiments; N, total number of analyzed embryos; n.s., not significant. Error bars indicate standard error of the mean (s.e.m.). * p≤0.05, ** p≤0.01. p values were calculated by a non-parametric Mann–Whitney rank sum test.
Image published in: Seigfried FA et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V.
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