Xenbase Image ID: 157284

Figure 8. Model for the specification of NPB cells. In response to Bmp, Wnt, and Fgf signaling, the transcription factors Pax3 and Zic1 are activated at the NPB. The activity of these two factors regulates the specification of three NPB cell populations. When Pax3 and Zic1 reach an appropriate balance, NC is induced (A). Variations in the relative activity of these two transcriptional regulators at the NPB can disrupt this balance, either toward Pax3 to promote HG formation (B) or toward Zic1 to promote PE fate (C). Image published in: Hong CS and Saint-Jeannet JP (2007) Copyright © 2007. Image reproduced with permission of the Publisher, American Society for Cell Biology (ASCB). This is an Open Access article. Larger Image Printer Friendly View

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