Xenbase Image ID: 157432

Figure 5—figure supplement 1. The EC domains of SMOC and Pent are conserved and share structural homology to BM-40. (A) Predicted heparin binding sequence of hSMOC-1 aligned with the same region of XSMOC-1 and Pent. Conserved amino acids are shown in bold and basic amino acids are shown in red. (B) Unsupervised homology model for the XSMOC-1 EC domain, based on the structure of the EC domain of BM-40 (1SRA.pdb), constructed using the Protein Homology/analogy Recognition Engine (PHYRE, RRID:SCR_010270). The XSMOC-1 EC domain aligns in the exact orientation with the BM-40 model; alpha helices E and F are noted. (C) Electrostatic surface potential maps (based on solvent accessibility) of the EC domains of XSMOC-1 and BM-40 showing an area of positive charge (shown in blue) in XSMOC-1 that is absent in the equivalent region of BM-40. DOI: http://dx.doi.org/10.7554/eLife.17935.012 Image published in: Thomas JT et al. (2017) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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