Xenbase Image ID: 157435

Figure 8. Schematic diagrams showing the proposed mode of action of Pent in the Drosophila wing disc and SMOC in vertebrate joint interzones. (A) Representations of the expression patterns of pent (Vuilleumier et al., 2010) dally (Fujise et al., 2003) and Dpp signaling (pMad) (Vuilleumier et al., 2010) in wild type Drosophila wing discs, compared with (B) pent−/− or (C) dally−/− mutant discs. The expression patterns observed in the absence of pent or dally (Vuilleumier et al., 2010) are consistent with Pent/Dally binding being required to expand the range of Dpp signaling. (D) Expression patterns of SMOC (Okada et al., 2011; Rainger et al., 2011), Syndecan-3 (Koyama et al., 1995), and BMP signaling (pSmad) [4949] in a developing vertebrate autopod joint, compared with that predicted for (E) the absence of HSPGs (HS−/−), or (F) the absence of SMOC (SMOC−/−). DOI: http://dx.doi.org/10.7554/eLife.17935.016 Image published in: Thomas JT et al. (2017) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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