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Supp. F2. Apoptosis is not upregulated in BMO1 morphants. X. laevis embryos were radially injected with CoMo or BMO1 as in Fig 1 and immunostained for activated Caspase-3 protein at early gastrula stage (NF10.5). No apoptotic cells were detected. As positive control, the embryo in panel A was injected with an expression plasmid for the proapoptotic factor FADD (60pg/embryo) into the DMZ. Dashed white line delineates the field, where FADD induced apoptosis; white asterisks indicate background staining on the blastocoel walls; inserts: dorso-vegetal views. Black dashed line marks the extent of the blastopore lip. Image published in: Wagner G et al. (2017) © 2017 Wagner et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue casp3.2.L Apopain, CASP-3, caspase 3, caspase-3, xCPP32 X. laevis Throughout NF stage 11 apoptotic cell Image source: Published Larger Image Printer Friendly View

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