Xenbase Image ID: 157592

Figure 6 Model of apoptosis regulation in Xenopus embryos. Ionizing radiation promotes apoptosis in embryos irradiated before the MBT by triggering different proapoptotic factors, including the homodimerization of xBax, and caspase cascade activation. Apoptosis is prevented in embryos irradiated after the MBT by the coordinated action of antiapoptotic stimuli. Survival signaling pathways act at at least three levels: by promotion of cell cycle delay by increasing the amount of p27Xic1 and its association with the complexes involved in the G1/S transition, by inactivation of proapoptotic molecules by heterodimerization, and by activation of antiapoptotic pathways like Akt. Image published in: Finkielstein CV et al. (2001) Copyright © 2001. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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