XB-IMG-157691
Xenbase Image ID: 157691
|
Figure 6 Expression of TNF-a and IL-1b in the RPE and
choroid at Day 1 after retinal removal (A), and expression
of TNF-a and IL-1b, Xmmp9, and Xmmp18 in cultured tissues
(B). (A) Twenty-four hours after retinal removal, both
cytokine genes are markedly upregulated, indicating that
inflammatory reaction had begun in the choroid. Three to
four animals were used either for the control or Day 1 after
retinal removal. (B) In the culture, expression of TNF-a
and IL-1b is clearly observed on Day 3 and the expression
level decreased considerably on Day 20. Expression of
Mmp9 and Mmp18 exhibits a similar profile to that of cytokine
genes. In the presence of 10 mM Withaferin A (W),
expression levels of these genes on Day 3 substantially
decreased. Three separate experiments were performed and
representative data are shown in the figure. *, p<0.05; **,
p<0.01 vs. cultured at Day 0. [Color figure can be viewed
at wileyonlinelibrary.com] Image published in: Naitoh H et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, John Wiley & Sons. Larger Image Printer Friendly View |