Xenbase Image ID: 157780

Figure 1 DNA binding and dimerization of the P328L329 mutant. (a) Scheme of the related human transcription factor HNF1α and HNF1β with the frameshift mutations P328L329fsdelCCTCT (P328L329) and R137-K161del. The various domains are indicated, and the numbers refer to the amino acid positions. The homology between HNF1α and HNF1β is given (2). (b) Gel-retardation assay using the 32P-labeled HNF1-binding site as a probe. The additions of the various in vitro translation products and of the antibodies are given. The heterodimers are marked with an asterisk. The methods used are described (21). Image published in: Wild W et al. (2000) Copyright © 2000. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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