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Supplementary Figure 6 – Severe and persistent neural tube closure defects in sall morphants (A-D) Stage 16 embryos after bilateral injection of morpholino(s); dorsal view, anterior up. Asterisks in images indicate injected side; white arrowheads indicate normal forming neural fold; black arrowheads indicate failed neural fold formation. Quantification (E) shows the percentage of embryos with closing (white bars) or open (grey bars) neural tubes. This represents total combined data including splice-blocking and translation-blocking morpholino experiments. n > 40 embryos per experimental condition; *** p < 0.001 by pairwise chi-squared test. (F-I) Stage 23 embryos after unilateral injection of morpholino(s); dorsal view, anterior up. Asterisks in images indicate injected side. Quantification (J) shows the percentage of embryos with closing (white bars) or open (grey bars) neural tubes. This represents total combined data including splice-blocking and translation-blocking morpholino experiments. n > 15 embryos per experimental condition; *** p < 0.001 by pairwise chi-squared test. Related to Figure 3 A-E. Image published in: Exner CRT et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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