Xenbase Image ID: 158084

Fig. 1. Xenopus TIMP3. Sequence comparison of human, mouse, rat, chicken, bovine and Xenopus TIMP3. SP is signal peptide cleavage site. Primers show two conserved TIMP sequences that were used in degenerate primer designed and TIMP3 cloning. Consensus shows identical amino acids in all six sequences. Twelve conserved cysteines are shown in bold. In human TIMP3, boxes refer to point mutations that all generate cysteine and cause a rare dominantly inherited eye disease called Sorsby fundus dystrophy ( Felbor et al., 1997). Circle is a conserved Asn residue and potential site for N-linked surgars. Image published in: Yang M and Kurkinen M (1998) Copyright © 1998. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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