Xenbase Image ID: 158598

Fig. 2. Anterior neural tube closure defects inhmmrmorphants. (A) Single frames from time-lapse movie during neurulation of embryos injected into both dorsal animal blastomeres with control morpholino (MO) or hmmr MO. Three different time points corresponding to control stages (st.) 13, 15 and 19 are shown in dorso-anterior views. Dashed white lines mark the border between superficial neural and non-neural ectoderm, dashed black lines indicate midline. Green arrowheads indicate wildtype distance of neural folds, red arrowheads indicate increased anterior neural fold distance in morphants. (B) Statistical analysis of anterior neural fold distance relative to control at st. 19. Number of embryos indicated above each plot. (C) Transverse histological sections of posterior or anterior neural tissue at st. 17 or 21 of embryos injected unilaterally into a single dorsal animal blastomere (injected side indicated by asterisk) with hmmr MO or vangl2 MO. Borders of neural tissue are marked in white. Wildtype or aberrant neural fold convergence indicated by green or red arrowheads, respectively. Image published in: Prager A et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, Elsevier B. V. Larger Image Printer Friendly View

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