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Figure 1. Distinct compositions of GARLHed and GARLHless GABAARs.Cerebellar membranes solubilized with lauryl maltose-neopentyl glycol (MNG) were subjected to BN-PAGE. The α6 and δ GABAAR subunits preferentially migrated at 480 kDa, while γ2 and α1 as well as GARLH4 and neuroligin-2 (NL2) predominantly migrated at 720 kDa. β2/3 signal was observed equally at 480 and 720 kDa. The arrow and arrowhead indicate the GARLHed and GARLHless GABAAR, respectively, while the asterisk (*) denotes the NL2 band without GABAARs. The images are representative of three independent experiments. Image published in: Martenson JS et al. (2017) © 2017, Martenson et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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