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Fig. 5. Prdm13 expression in the retina upon Ptf1a gain and loss of function. a Double fluorescent in situ hybridization with prdm13 (red) and ptf1a (green) probes on wild type retina at stage 35/36 and 40. Right panels are enlargement of central or peripheral retina (white squares). Arrows show double labelled cells. b Quantification of the percentage of ptf1a + cells among the prdm13 + cell population (top graph) and the percentage of prdm13 + cells among the ptf1a + cell population (bottom graph) at different stages of retinogenesis. Data are presented as mean ± SEM. Number of analysed sections is indicated in each bar. c Analysis of gad1, prdm13 and glyt1 expression on stage 41 retinal transversal sections following whole mount in situ hybridization on embryos injected with ptf1a-MO, control-MO, GFP mRNA (control) or ptf1a-GR mRNA. Dexamethasone was added at stage 21/22 to activate the Ptf1a-GR fusion protein. Scale bar represents 100 μm Image published in: Bessodes N et al. (2017) © The Author(s). This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue prdm13.L X. laevis Sometime during NF stage 35 and 36 to NF stage 40 retina retinal neural layer ptf1a.S ptf1a-a, ptf1a-b, Ptf1a/p48, XPtf1a X. laevis Sometime during NF stage 35 and 36 to NF stage 40 retina retinal neural layer gad1.1.L cpsq1, gad67 X. laevis Throughout NF stage 40 retina retinal neural layer prdm13.L X. laevis Throughout NF stage 40 retina retinal neural layer slc6a9.L glyt1, glyt1b, xGlyT1 X. laevis Throughout NF stage 40 retina retinal neural layer Image source: Published Larger Image Printer Friendly View

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