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Fig. 3. Vgll3 stimulates pax3 and zic1 expression. (A) Embryos were injected with v3MO or vgll3 mRNA and analysed at stage 19 for pax3 and zic1 expression. Defects of CNC lateral streams and trigeminal placode are shown by arrows and arrowhead respectively. (B) ISH for vgll3 and pax3 shows overlapping expression at the r2 level (blue arrow). (C) Stage 19 embryos injected with pax3GR/zic1GR mRNAs show a faint vgll3 and a strong snail2 expression after dexamethasone treatment (+dex). (D) cMO/LacZ mRNA control and quantification. Three independent experiments were performed (n=40). (*), injected side. All views are dorsal-anterior. A dotted line indicates the midline embryo. (E) ISH for vgll3 and zic1 shows overlapping expression at the r2 level (blue arrow). Zic1 expression in stage 21 embryo. Image published in: Simon E et al. (2017) © 2017. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue pax3.L cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 19 neuroectoderm neural plate cranial neural crest preplacodal ectoderm zic1.L odd-paired-like, opl, Zic-r1, Zic-related-1 X. laevis Throughout NF stage 19 neuroectoderm neural plate cranial neural crest vgll3.L LOC108709205 X. laevis Throughout NF stage 15 presumptive rhombomere neuroectoderm neural plate pax3.L cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 15 presumptive rhombomere neuroectoderm neural crest neural plate preplacodal ectoderm vgll3.L LOC108709205 X. laevis Throughout NF stage 18 presumptive rhombomere neuroectoderm neural plate pax3.L cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 18 presumptive rhombomere neuroectoderm neural crest neural plate preplacodal ectoderm pax3.L cdhs, hup2, pax-3, pax3-a, pax3-b, Waardenburg syndrome 1, ws1, xpax3 X. laevis Throughout NF stage 21 neuroectoderm neural crest neural plate preplacodal ectoderm vgll3.L LOC108709205 X. laevis Throughout NF stage 14 presumptive rhombomere neuroectoderm neural plate vgll3.L LOC108709205 X. laevis Throughout NF stage 21 presumptive rhombomere neuroectoderm neural plate zic1.L odd-paired-like, opl, Zic-r1, Zic-related-1 X. laevis Throughout NF stage 14 neuroectoderm neural crest neural plate presumptive rhombomere zic1.L odd-paired-like, opl, Zic-r1, Zic-related-1 X. laevis Throughout NF stage 18 neuroectoderm neural crest neural plate presumptive rhombomere zic1.L odd-paired-like, opl, Zic-r1, Zic-related-1 X. laevis Throughout NF stage 21 neuroectoderm neural crest neural plate presumptive rhombomere vgll3.L LOC108709205 X. laevis Throughout NF stage 19 neuroectoderm neural plate presumptive rhombomere snai2.L slug, snai2-a, snai2-b, Snail2, xSlu, xslug, XSnail2 X. laevis Throughout NF stage 19 neuroectoderm neural crest neural plate neural plate border cranial neural crest Image source: Published Larger Image Printer Friendly View

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