XB-IMG-159178
Xenbase Image ID: 159178
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Figure 6: Model for HCN4 function in establishing laterality.
The developmental timeline along the left illustrates early cleavage stages to
post-gastrulation asymmetric gene expression of the Nodal-Lefty-Pitx2 cascade
leading to final organ situs. Previously established important laterality events are
outlined adjacent to the developmental time line and portray very early laterality
events of cytoskeletal rearrangement and physiological amplification, as well as later events such as gastrulation-stage ciliary flows, all funnel into the canonical Nodal-
Lefty-Pitx2 gene regulatory network to bring about invariant asymmetric organ situs.
HCN4 action is required during early clevage stages and can largely bypass the Nodal-
Lefty asymmetric gene expression cascade to affect organ situs. HCN4 mediated
Nodal-Lefty asymmetric gene expression-independent effect could be due to directly
acting on downstream factors of the Nodal-Lefty pathway or through a non-canonical
pathway. Players in this HCN4 mediated laterality patterning remain to be discovered. Image published in: Pai VP et al. (2017) © 2017. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |