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Figure S1: HCN4 channel inhibitor, ivabradine affects left-right organ laterality only upon early exposure of embryos (st. 1-10). (A) Quantification of stage 45 tadpoles for left-right organ (Heart, Gut and Gallbladder) laterality with or without exposure to 400μM ivabradine at 22 ºC at the indicated stages. A significantly high incidence of heterotaxia was observed in embryos exposed to ivabradine between stages 1 -10 in comparison to controls. Embryos exposed to ivabradine late (st. 10-40) did not show any significa nt increase in the incidence of leftright organ misplacement. The experiment was conducted in triplicates and data was pooled to run a χ2 analysis, ***p<0.001. Image published in: Pai VP et al. (2017) © 2017. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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