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Figure S1, Related to Figure 4. Model Validation (A) Varying the spatial heterogeneity along simulated embryonic axes results in simulated cell division waves with fit lines of varying slope. Simulation results were compared to experimentally measured slopes ± 1 standard deviation to yield a range of heterogeneities. The predicted heterogeneity for the animal-vegetal axis was used to calculate an expected difference in period between the animal and vegetal halves of an embryo. (B) Average slopes ± 1 standard deviation fit to experimentally measured data. Divisions four, five, and six contain comparatively less variation and contribute uniformly to wave development. Division 8 served as a benchmark for model calibration. (C) Predicted difference in average period between vegetal and animal cells matches with average measured period difference between these two hemispheres. Image published in: Anderson GA et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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