Xenbase Image ID: 159403

Figure 6 NeuroD misexpression disrupts Pax-6 expression. All embryos were injected with NeuroD on the left side. In all panels dorsal is up. (A) Stage 14 neural plate stage, viewed anteriorly. The arrowhead shows the loss of the medial stripe of Pax-6 expression. Expression in the anterior crescent is reduced, but not eliminated (arrow). (B) A stage 23 embryo, viewed anteriorly. The area on the embryo’s left, where the eye should be, is outlined in black. The arrow indicates the forebrain staining on the injected side, which is largely unaffected. (C) A transverse section through a stage 26 embryo at the level of the eye. The staining in the brain on the injected side is reduced but not eliminated (arrow). Note the absence of an eye on the injected side (region outlined in black). Pax-6 expression is still visible in the presumptive lens epithelium (PLE) on the uninjected side (arrowhead). Scale bar 200 mm. Image published in: Hirsch N and Harris WA (1997) Copyright © 1997. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Throughout NF stage 14 neural plate anterior neural fold pax6.L an2, mgda, pax-6, pax6-a, pax6-b, wagr, XLPAX6, xpax6 X. laevis Sometime during NF stage 23 to NF stage 26 neural tube anterior neural tube optic vesicle Image source: Published Larger Image Printer Friendly View

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