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Fig 3. Nonnegative matrix factorization (NMF) efficiently deconvolutes differential expression profiles. The NMF algorithm defines a set of ectoderm tissues (NMF-tissues) at Nieuwkoop and Faber stage (St.) 12.5 (A) and St. 14 (B). Columns in the mixing matrix indicate how these tissues contribute to the initial dissected samples. Red indicates high contribution; blue indicates low/no contribution. Interesting intermediate contributions are outlined by white dotted lines; stars (*) refer to comments in text. From these contributions, dissected samples (left part of the pattern drawn on embryo) were matched with 1 of the NMF-tissues (right part of the pattern). At St. 12.5, striped pattern indicated the mixed contribution of posterior neural plate and neural border (NMF-NP(p), NMF-NB(p)) to NBp samples. Abbreviations and colors are the same as in Fig 1 and S1 Table. Image published in: Plouhinec JL et al. (2017) © 2017 Plouhinec et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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