Xenbase Image ID: 159580

Fig 6. Distribution of Wnt-responding genes and genes involved in neural, neural crest (NC), and placodal development across weighted gene co-expression network analysis (WGCNA) synexpression groups. The histogram shows how many transcripts were found in each synexpression group and if this represented a significant enrichment compared to uniform distribution in all groups; see S11 Table for numerical data. (A) The Wnt-responsive transcripts identified by Kjolby and Harland [49] were mainly distributed in 4 co-expression groups: 47% of the genes positively regulated by Wnt signaling from the input list were found in groups #23, #31, and #41, while 62% of genes negatively regulated by Wnt were found in group #92. Group #23 contained posterior genes (e.g., cdx1/2/4, hes5/9, ngfr, kremen2); group #31, Wnt-signaling components (xarp, tcf7); group #41, meso-endoderm specifiers (e.g., msgn1, myf5, t, vegt); and group #92, genes up-regulated in absence of Wnt signaling. (B) Placodal and NC genes were enriched in groups #38 (43% of the input list) and #51 (70% of the input list), respectively. Contrarily to NC markers, the neural border genes, many of which are more broadly expressed, were distributed across many different co-expression groups; however, pax3 and myc were part of group #51. Image published in: Plouhinec JL et al. (2017) © 2017 Plouhinec et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

Return to previous page