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Fig 10. Genes linked to human melanoma are tightly associated with Wnt-associated genes and neural crest (NC) genes during development. (A) Several (26) genes linked to melanoma super-enhancers defined by Kauffman et al. (2016) were found among the posterior/Wnt genes group (#23) and the NC group (#51). (B) Cumulative frequency of genetic alterations found in these 26 genes in various cancer types: NC-derived cancers are outlined in purple. High mutation frequency (>45%) is found in melanomas. The nature of the genetic alteration is plotted along y-axis. We used 70 studies describing at least 100 tumors of each kind (TCGA). (C) These 26 genes were frequently mutated in cutaneous and uveal melanoma: this diagram displays genetic alterations found for each gene above 5% frequency, in 191 out of 287 cutaneous melanomas and in 24 out of 80 uveal melanomas. See S11 Table for numerical data. Panels (B) and (C) are based on data obtained by the TCGA Research Network: http://cancergenome.nih.gov and visualized by cBioPortal. Image published in: Plouhinec JL et al. (2017) © 2017 Plouhinec et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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