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S8 Fig. Distinction between ectoderm-enriched genes and posterior mesoderm-expressed genes by combining nonnegative matrix factorization (NMF) pattern and average expres- sion analysis. In complement to average or NMF-predicted expression patterns, we indicate the enrichment of gene expression in ectoderm, compared to whole embryo expression. Ecto- derm enrichment index allows distinguishing between genes highly and specifically expressed in the ectoderm germ layer (e.g., sox10, dark green, expression of which is initiated at stage 14) and genes found in the posterior neural tissue because of attached mesoderm cells (myod, myf5, yellow, low level). All intermediate situations are found, including ubiquitously expressed genes or genes enriched in 1 dissected region but not in the others. Ec = NNE, non- neural ectoderm. See S11 Table for numerical data. Image published in: Plouhinec JL et al. (2017) © 2017 Plouhinec et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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