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S12 Fig. Analysis of evolution of snail2 homeologous gene pair. Snail2.l and snail2.s exhibit differential expression with asymmetrical decrease of snail2.s (S11 Fig). (A) Tree for snail2 genes. Snail2.l, the copy with retained expression in X. laevis, is closer to X. tropicalis gene than to X. laevis snail2.s. (B) In X. laevis, mutations are accumulating in the low complexity regions of Snail2.s protein compared to Snail2.l or X. tropicalis Snail2. (C) Detail of the mutation observed on Snail2 proteins. (D) Protein alignment confirms that the mutations in Snail2.s are found on residues conserved in other vertebrates. Image published in: Plouhinec JL et al. (2017) © 2017 Plouhinec et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View |