Xenbase Image ID: 159698

Figure 6. Effects of VPA on T17M-transgenic retinas are reproduced by the HDACi's sodium butyrate (NaBu) and CI-994. A–C, Effects of NaBu on light exacerbated RD in T17M animals were essentially identical to the effects of VPA. Panels are as described in Figure 3, A–C (two-way ANOVA, cyclic light: pg = 3.7 × 10−15, pt = 1.6 × 10−9, pi = 4.2 × 10−6; two-way ANOVA, dark: pg = 0.002, pt = 0.29, pi = 0.77). n = 8–14 animals per group. D–F, Effects of CI-994 on light-exacerbated RD in T17M animals were essentially identical to the effects of VPA. Panels are as described in Figure 3, A–C (two-way ANOVA, cyclic light: pg = 6.1 × 10−11, pt = 5.2 × 10−8, pi = 2.6 × 10−5; two-way ANOVA, dark: pg = 0.156, pt = 0.013, pi = 0.538). n = 8–13 animals per group. Image published in: Vent-Schmidt RYJ et al. (2017) Copyright © 2017. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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