Xenbase Image ID: 159700

Figure 8. Transmission electron microscopy of X. laevis rod photoreceptors. A, B, Untreated WT. C, D, VPA-treated WT. Structures indicated by arrowheads are consistent with autophagosomes or autolysosomes. Structures indicated by arrows are consistent with newly forming autophagosomes (phagophores). Small vesicular structures morphologically consistent with autophagosomes and autolysosomes increased with VPA treatment consistent with an increase in autophagy. E, Vesicular structures also increased in rods treated with sodium butyrate. F, Vesicular structures were increased in photoreceptors expressing P23H rhodopsin, consistent with previous studies suggesting induction of autophagy during retinal degeneration. Larger vesicular structures were also apparent in these samples. C′, E′, F′, Boxed structures from C, E, and F shown at higher magnification. M, Mitochondria; ER, endoplasmic reticulum; N, nucleus. Scale bar, 500 nm. Image published in: Vent-Schmidt RYJ et al. (2017) Copyright © 2017. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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