Xenbase Image ID: 159701

Figure 9. Electroretinography (ERG) of X. laevis tadpoles treated with HDACi's. A, B-wave amplitudes obtained from VPA-treated and untreated WT and P23H X. laevis tadpoles in response to flashes of increasing intensities. Two-way ANOVA shows a significant effect of intensity and group (p = 7 × 10−17, p = 4.1 × 10−4). n = 5–7 animals per condition. Multiple comparisons (Tukey's test) showed that P23H untreated responses were significantly different from all other groups (p < 0.019) and no other differences between groups were significant. B, Representative ERG traces from each condition in A. C, B-wave amplitudes obtained from sodium butyrate (NaBu)-treated and untreated P23H X. laevis tadpoles in response to increasing flash intensities. Two-way ANOVA showed a significant effect of intensity and group (p = 1.1 × 10−6, p = 0.012). Responses from treated P23H X. laevis improved significantly. D, Representative ERG traces from each condition in C. n = 4–8 animals per condition. Error bars indicate SEM. Image published in: Vent-Schmidt RYJ et al. (2017) Copyright © 2017. This image is reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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