Xenbase Image ID: 159708

Fig. 7. BMP/Smad1 and Wnt/β-catenin converge on the same FG and HG CRMs. (A) Model of how spatially restricted Wnt and BMP activity coordinate A-P and D-V patterning of FG and HG progenitors. A signaling crosstalk in the FG is illustrated, with low Wnt promoting BMP ligand expression in the pre-cardiac mesoderm. dFG and vFG, dorsal and ventral foregut. (B) A model of how overlapping Smad1 and β-catenin binding to DNA cis-regulatory modules might regulate transcription of different classes genes in FG (yellow column on left) versus HG (green column on right) tissue. Example genes for each regulatory category are indicated on the right. Y and Z indicate transcription factors other than Tcf. Solid arrows indicate the predominant activity in the cells, whereas dashed lines indicate activity that is insufficient to regulate transcription in the cells. Image published in: Stevens ML et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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