Xenbase Image ID: 159714

Fig. S6: BMP/Smad1 and Wnt/β-catenin crosstalk. (A) Overlap between BMP-regulated/Smad1-bound and Wnt-regulated/β-catenin-bound genes. (B) Browser view of β-catenin and Smad1 peaks in Xenopus and human genes (from GSM1505734 and GSM1579346). Red boxes indicate overlapping Smad1 and β-catenin peaks. Black boxes indicate syntenic peaks. (C) In situ hybridization of DMH1, Tg(hsp70:dkk1) and BIO treated embryos in mid-sagittal section, anterior left and dorsal up. Embryos are either stage NF12 wild-type or treated at stage NF11 and fixed at stage NF20. * indicates hhex-expressing FG cells. (D) Expression heatmap of BMP and Wnt ligands and targets present in FG and HG samples of controls (CO), DMH1, Tg(hsp70:dkk1) and BIO-treated embryos. Image published in: Stevens ML et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue bmp2.L BMP-2, bmp2-a, bmp2-b, xBMP-2, xbmp2 X. laevis Throughout NF stage 11 endoderm ventral marginal zone bmp4.L bmp-4, bmp2b, bmp2b1, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme X. laevis Throughout NF stage 11 animal hemisphere marginal zone bmp7.1.L bmp-7, bmp7, op-1 X. laevis Throughout NF stage 11 dorsal marginal zone animal hemisphere bmp2.L BMP-2, bmp2-a, bmp2-b, xBMP-2, xbmp2 X. laevis Sometime during NF stage 12 to NF stage 20 foregut mesoderm bmp4.L bmp-4, bmp2b, bmp2b1, bmp4-a, bmp4-b, DVR-4, ofc11, XBMP-4, xbmp4, zyme X. laevis Sometime during NF stage 12 to NF stage 20 hindgut foregut mesoderm ventral mesoderm bmp7.1.L bmp-7, bmp7, op-1 X. laevis Sometime during NF stage 12 to NF stage 20 hindgut foregut mesoderm ectoderm ventral mesoderm Image source: Published Larger Image Printer Friendly View

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