Xenbase Image ID: 159726

Figure S4. Similarities and differences in GFP patterns in transgenic DEVD- and LEHD-reporter tadpoles. (A) DEVD- and LEHD-reporter activity is present in the lens and the muscle, consistent with possible non-apoptotic caspase activity. Both the DEVD- (top) and the LEHD-reporter (bottom) reveal GFP expression in the cells forming the lens around stage 32-34 (left pictures, yellow arrowhead) and in individual myocytes in the late tadpole tail (middle pictures, with the boxed area enlarged in the right pictures). (B) Circulating GFP-positive blood cells are only present in LEHD reporter tadpoles. Tadpoles of DEVD-reporter (left) or LEHD-reporter (right) are shown around Nieuwkoop stage 39. GFP signal in the vasculature is due to circulating GFP-positive blood cells. No such activity is present in the DEVD reporter despite high transgene expression. Image published in: Tran HT et al. (2017) Copyright © 2017. Image reproduced with permission of the Publisher, The Company of Biologists Ltd. Larger Image Printer Friendly View

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