Xenbase Image ID: 159736

Fig. 7. Mathematical analysis of pulsed AC. (A) Mean tissue sizes of the modeled epithelial sheets during the time course of the simulations, and representative images at the end of each simulation. (B) Mean tissue constriction at the end of the simulations. In A and B, the pulsed contractions were introduced at a frequency of 0.025 simulation time−1 edge−1, and all of the cell edges in the activated cells were contracted. ***P<0.001, two-sided Student’s t-test. n.s., not significant. (C) Mean line tension, potential energy from the elasticity of apical surface area, area and natural area of single cell (#58) during the time course of the simulations with the pulse and Acn components. The period with pulse is highlighted in yellow. See Supplementary Materials and Methods for definitions. (D) Relationship between the pulse frequency and mean constriction at the end of the simulations. The proportion of cell edges undergoing contraction per cell was set to a probability ( pe) of 1, 0.5 or 0.25. (E) Mean tissue sizes during the time course of the simulations, when the active period in which the pulses were introduced was set from 200 to 2000 simulation times. (F,G) The mean constriction at the end of the simulations and the constriction rate during the active period, when the length of the active period and the proportion of the cell edges undergoing contraction per cell were changed. All error bars depict s.d.; n=5 different initial conditions. Details of the models and of the simulation processes are described in the supplementary Materials and Methods, Tables S1 and S2. Image published in: Suzuki M et al. (2017) Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

Return to previous page