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Figure S5. Mathematical analysis of pulsed apical constriction with varied assumptions. Mean tissue sizes of the modeled epithelial sheets during the time course of the simulations with the Acn component alone (black), and with the Acn components and the pulse whose active period was set from 200 to 2000 simulation times (colors). Basis of parameter values in the simulations is the same with Figure 7A (#2,4 in Table S2) and 7D (#43-46 in Table S2). (A) During the pulse, the coefficient of elasticity of cell’s apical surface area and perimeter are changed instead of the line tension; KA n = 0.2; KP n = 0.15. (B) σ1 = -0.1; σ2 = 0.1. (C) The cells’ natural surface area and the cells’ natural perimeter are permitted to increase: eq.7 and 8 were simplified to become dA0 n/dt = κA(An - ωAA0 n) and dP0 n/dt = κp(Pn - ωpP0 n); ωA = 0.7; ωP = 0.8. (D) The cells’ natural surface area and the cells’ natural perimeter are permitted to increase as shown in (C); ωA = 0.8; ωP = 0.7.

Image published in: Suzuki M et al. (2017)

Copyright © 2017. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.

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