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Fig. 3. Lotilaner is a potent antagonist of the DmS-GABA receptor. a Current traces from a cumulative exposure to increasing dosage of lotilaner obtained for a Xenopus oocyte expressing DmS-GABA. The bars indicate the time period of GABA (10 μM) application. The grey triangle represents the gradual exposure to lotilaner with the respective concentration in μM indicated above. b Averaged inhibition concentration-response curves measured for dieldrin (black circle), fipronil (black triangle, dashed line), lotilaner (black square), and AHC-2229544 (white square) obtained from oocytes expressing DmS-GABA. Individual curves were standardized to the fitted maximal current amplitude and subsequently averaged. Mean ± SEM of experiments carried out with at least four oocytes from two batches each is shown Image published in: Rufener L et al. (2017) © The Author(s). This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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