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Fig. 7. Lotilaner is a potent antagonist of invertebrate GABACl receptors. Averaged inhibition concentration-response curves for lotilaner and fipronil measured on oocytes expressing Ls-GABA1 (white circle and black triangle, dashed line) or Rm-GABA (black square and white diamond, dashed line) as well as on Cl-GABAA α1β2γ2 (white square) for lotilaner. Individual curves were standardized to the fitted maximal current amplitude and subsequently averaged. Mean ± SEM of experiments carried out with at least four oocytes from two batches each is shown Image published in: Rufener L et al. (2017) © The Author(s). This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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