Xenbase Image ID: 168478

Fig. 6. Novel modes of endoderm gene regulation. (A-O) Each of the 301 endoderm-enriched transcripts was placed in a category based on how it was regulated in Nodal- (N), Mixer- (M) and Sox17- (S) embryos, based on the criteria of 1.4-fold change in expression levels relative to stage 11 control embryo. Genes downregulated more than 1.4-fold in Nodal-, Mixer- or Sox17- embryos were classified as positively regulated by Nodal proteins (+N), Mixer (+M) or Sox17 (+S), respectively. Genes upregulated more than 1.4-fold in Nodal-, Mixer- or Sox17- embryos were classified as negatively regulated (-), i.e. normally repressed, by Nodal proteins (-N), Mixer (-M) or Sox17 (-S), respectively. Genes with less than a 1.4-fold change in expression levels relative to controls were considered to be `not obviously regulated' by Nodal proteins (0N), Mixer (0M) or Sox17 (0S), respectively. The number of genes in each category is indicated in red. The simple linear model of endoderm development predicts only coordinate positive regulation by Nodal proteins, Mixer and Sox17 (A, blue box). The endoderm-enriched transcriptome is complex and can be classified into 19 different categories. A, animal cap; V, vegetal region; E, equatorial region; W, whole embryo. Image published in: Sinner D et al. (2006) Copyright © 2006. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Larger Image Printer Friendly View

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