Xenbase Image ID: 168530

Figure 1. Quantitative changes of the X. laevis proteome over seven developmental stages. (A) Micrographs of X. laevis at the developmental stages taken for proteomic analyses. (B) Individual protein abundance presented on a log2 axis across developmental time points. Data are normalized to the mean value of each protein. (C) Relative standard deviation (RSD) for all proteins in panel (B) at individual experimental time points. (D) Heatmap showing the change in protein expression across the developmental time points. The heatmap was generated from the log2 normalized data using the default parameters in Matlab. Six groups representing significant trends of protein expression were manually selected for analysis. Proteins with the 15% greatest quantitative change are presented and are considered significant at a FDR of 0.20 using a Benjamini-Hochberg test. Neither clustering nor dendrogram generation was performed along the development stage axis of the heatmaps. These points are defined by the biology of development, and their differences are fixed by that biology. Image published in: Peuchen EH et al. (2017) © The Author(s) 2017. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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