Xenbase Image ID: 169118

Fig 4. Phenotypes predicted by the BNE.The phenotype profile used for the mapping is based on the 11 genes present in both the Boolean model and the Xenopus analysis. The figure in the left panel shows the distance curves for the nearest phenotypes and fixed points. The x-axis denotes the values of the parameter exogen_canWnt_I and the phenotypes to which the fixed points were mapped. The y-axis shows the actual distance. The phenotypes are ordered by increasing exogen_canWnt_I expression propensity (right panel). Activated genes are shown in green and deactivated genes are shown in red. The framed box shows the gene expression propensity pattern for the four genes Isl1, Nkx2.5, Tbx1, and Tbx5 that corresponds to the the RT–PCR phenotypes of the FHF and SHF from the Fig 3. The FHF_BOOL and SHF_BOOL phenotypes correspond to the phenotypes found in the Boolean model [16]. The SHF1 phenotype is split in three sub-phenotypes PH-1076, PH-564, and PH-692 that differ by the gene expression propensity of canWnt, Bmp2, and Fgf8. The expression of the Fgf8 gene was not reported in Xenopus. Its activation pattern is a prediction of the BNE. Image published in: Grieb M et al. (2015) Image reproduced on Xenbase with permission of the publisher and the copyright holder. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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