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Figure 2. Global fit of concentration-activation relationships from five CNGA2 concatamers.(a) Markovian submodels describing the activation gating of five concatamers. The closed-open isomerizations, including their equilibrium constants, E0….E4, are indicated only once at the bottom. They are the same for each equally liganded state. KA1H, KA2H, KA3H, KA4H, KA1L, KA2L, KA3L, and KA4L are the equilibrium association constants for the four high and low affinity binding sites, respectively. E0 and E4 were set to 1.7 × 10−5 and 9.9 × 101 according to the single-channel experiments. (b) Global fit of the data points of the five concatamers shown in a. The values of the equilibrium constants are provided by Table 1. (c) Occupancy of the states (P) predicted by the 1wt-submodel as function of the [cGMP]. Image published in: Wongsamitkul N et al. (2016) Copyright © 2016, Macmillan Publishers Limited. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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