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Fig 5. Kavain modestly reduced etomidate potentiation, but did not affect the direct activation caused by etomidate at α1β2γ2L GABAARs.Top, Representative traces of current responses elicited by 10 mM GABA (control); 10 μM GABA; 10 μM GABA and 300 μM kavain; 10 μM GABA and 3 μM etomidate; 10 μM GABA, 300 μM kavain and 3 μM etomidate; 30 μM etomidate; 30 μM etomidate and 300 μM kavain. Bottom, Kavain caused a subtle but significant reduction in etomidate potentiation (G2 + E1 vs. G2 + K + E1; n = 7; p < 0.01; paired t test), but had no effect on etomidate activation (E2 vs. E2 + K; n = 6; p > 0.05; paired t test). Data are normalised to the 10 mM GABA responses, and are presented as mean ± SEM. Image published in: Chua HC et al. (2016) © 2016 Chua et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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