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Fig 6. Kavain did not affect propofol potentiation, but modestly reduced propofol activation at α1β2γ2L GABAARs.Top, Representative traces of current responses to 10 mM GABA (control); 10 μM GABA; 10 μM GABA and 300 μM kavain; 10 μM GABA and 10 μM propofol; 10 μM GABA, 300 μM kavain and 10 μM propofol. Middle, Continuous traces demonstrating two consecutive applications of control (100 μM propofol) followed by the co-application of 300 μM kavain with control; and control. Bottom, Receptor modulation produced by propofol alone (G2 + P) was not significantly different from the combination of kavain and propofol (G2 + K + P; n = 5; p > 0.05; paired t test). The agonist effect of propofol (P2) was significantly reduced in the presence of kavain (P2 + K; n = 5; p < 0.01; paired t test). Data are presented as mean ± SEM. Image published in: Chua HC et al. (2016) © 2016 Chua et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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