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Fig 7. The pronounced effect of β3N265M point mutation on etomidate and propofol sensitivity.(A) Representative traces demonstrating the modulatory effect of 3 μM etomidate and 10 μM propofol on GABA EC3 (left) and the agonist effect of 30 μM etomidate and 100 μM propofol relative to 10 mM GABA (right) at α1β3γ2L and α1β3N265Mγ2L GABAARs. (B) The modulatory and agonist effects of etomidate and propofol were markedly diminished at α1β3N265Mγ2L GABAARs. Data are normalised to current responses elicited by 10 mM GABA, and are presented as mean ± SEM. *** p < 0.001; **** p < 0.0001; unpaired t test (mutant vs. wild-type). Numbers above bars indicate number of experiments. GABA + ETO: GABA EC3 + 3 μM etomidate; ETO: 30 μM etomidate; GABA + PRO: GABA EC3 + 10 μM propofol; PRO: 100 μM propofol. Image published in: Chua HC et al. (2016) © 2016 Chua et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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