Xenbase Image ID: 169879

Figure 5. CPLANE mutant mice display diagnostic features of Oral-Facial-Digital Syndrome Type 6(a and b) Frontal sections at E14.5 reveal that Fuz mutant mice display high arched palate (arrow) and lobulation of the tongue (arrowheads). (c and d) Fuz mutant mice display develop polydactyly with Y-shaped metacarpals. (e) Wdpcp mutant mice display develop polydactyly with Y-shaped metacarpals. (f, g, h) Frontal sections of E13.5 Wildtype, Wdpcp and Fuz mutant embryos. DAPI labels nuclei (cyan). (f’, g’, h’) Illustrations highlighting the corresponding palatal condensations (purple) and tongue (pink) in F-H. Mutant palatal condensations form more medially than do controls and fail to extend into the mouth (See Tabler et al., 2013). Image published in: Toriyama M et al. (2016) Image downloaded from an Open Access article in PubMed Central. Image reproduced on Xenbase with permission of the publisher and the copyright holder. Larger Image Printer Friendly View

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