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Figure 4. Immunofluorescence analysis of p‐STAT3 in R stage animals after SCI. Sections through the spinal cord of regenerative animals analyzed for pSTAT3 (green) and TOTO3 (nuclei, blue). (A), (A′) Sagittal section through the caudal portion of a spinal cord at 3 hpt. White arrows show positions for the stump and 200−600 μm caudal to the lesion site. (B), (B′) Coronal section from an uninjured spinal cord. (C)−(E′) Coronal sections from a transected animal at 3 hpt at (C), (C′) the stump level and (D), (D′) 200 and (E), (E′) 600 μm caudal to the lesion site. Arrows indicate representative pSTAT3+ cells in the ventricular zone (white arrows) and in the grey matter (white arrowheads). (F), (F′) Coronal sections at 1 dpt at 200 μm caudal to the injury site. (G), (G′) Coronal section at 6 dpt at 200 μm caudal to the injury site. Dotted lines delimit the central canal. White bars indicate 100 μm (A), (A′) and 50 μm (B)−(G′). The sections depicted are representative of three animals per time point. Image published in: Tapia VS et al. (2017) © 2017 The Authors. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Gene Synonyms Species Stage(s) Tissue stat3.L aprf, hies, stat3.1, Xstat3 X. laevis Sometime during NF stage 50 to NF stage 54 regenerating tissue Image source: Published Larger Image Printer Friendly View

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