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FIGURE 3. Mitotic rate. Micrographs of transverse sections through the pallium of Xenopus laevis at embryonic (A,B), premetamorphic (C) and prometamorphic (D) stages showing the distribution of PH3, marker of proliferating and mitotic cells, in combination to DAPI. During development, mitotic cells were observed in the ventricular cell layer, but also abventricularly (arrowheads in A–D). The mitotic index significantly increased at the end of the embryonic period, but it significantly decreased at early larval stages, to drastically increase later at stage 54, when a neurogenetic peak is observed (E). This pattern is observed not only in the pallium, but also when pallial and subpallial regions separately analyzed, where significant differences in their mitotic index were not observed at any stage (F). Considering separately during development the DM and the VL, major differences in their mitotic index were not observed, with the exception of the stage 37/38 when the dorsomedial proliferation is slightly higher, but it did not continue later in development (G). Scale bars = 50 μm (A–C), 200 μm (D). See list for abbreviations. ∗∗P < 0.001, ∗P < 0.05. Image published in: Moreno N and González A (2017) Copyright © 2017 Moreno and González. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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