Xenbase Image ID: 170220

Figure 8. Model for the evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes.(a) Schematic ancestral vertebrate with internal gills. Neural crest-derived (magenta) chromaffin cells are associated with large blood vessels in the pharyngeal arches, while NECs differentiate within the endoderm-derived (green) epithelium lining the gills and orobranchial cavity. (b) During the transition to terrestrial life, the glomus cells of the carotid body evolved via the aggregation of neural crest-derived chromaffin cells (which must also have acquired serotonergic properties), while (c) NECs persisted as PNECs in lung airway epithelia. Yellow arrows indicate shared ancestry. Bv, blood vessel; NEC, neuroepithelial cell; PNEC, pulmonary neuroendocrine cell.DOI: http://dx.doi.org/10.7554/eLife.21231.016 Image published in: Hockman D et al. (2017) © 2017, Hockman et al. This image is reproduced with permission of the journal and the copyright holder. This is an open-access article distributed under the terms of the Creative Commons Attribution license Larger Image Printer Friendly View

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